Nov 12, 2019 · The JAK/STAT pathway is evolutionary highly conserved and transmits extracellular signals to the nucleus modulating target gene transcription.
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Dec 19, 2019 · Janus kinase (JAK) inhibitors are widely used in the treatment of multiple autoimmune and inflammatory diseases.
Ruxolitinib is a small-molecule inhibitor of the JAK kinases, which has been approved for the treatment of myelofibrosis, a rare myeloproliferative neoplasm ...
The JAK/STAT signaling cascade is critical for NK cell development, maturation, survival, and proliferation, therefore, it is important to understand the role ...
Jul 13, 2016 · The results we present here show that inhibition of the JAK pathway, despite blocking STAT activation in tumour cells, enhances metastatic ...
Conclusion: NK cell proliferation depends on JAK1 and JAK3-mediated signaling and is differentially inhibited at clinical doses of distinct JAKinibs. In ...
Ruxolitinib is a small-molecule inhibitor of the JAK kinases, which has been approved for the treatment of myelofibrosis, a.
Oct 29, 2019 · JAK inhibitors alter NK cell functions and may impair immunosurveillance against lymphomagenesis ... An increased risk of B cell lymphomas in ...
Oct 17, 2019 · Natural Killer (NK) cells are the founding members of the ILC family ... JAK inhibition impairs NK cell function in myeloproliferative neoplasms.
Nov 14, 2023 · ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4.